Evaluation of the Effect of Erynjium Alcoholic Extract on Increasing Insulin Sensitivity: By Evaluating Hyperglycemia and Dyslipidemia in an Animal Model of Insulin Resistance

Introduction: Insulin resistance is a common complication of obesity in communities, so effective and available treatment for this disorder is necessary. The aim of this study was to investigate the effect of Eryngium Billardieri extract on insulin resistance in animal models. Methods: 30 Wistar rats were prepared from Baqiyatallah University Animal house and randomly divided into control (N = 6) and case (N = 24) groups. After preparing a blood sample,they were fed a normal and high-fat diet for 13 weeks, respectively, and at the end, blood samples were taken again and serum cholesterol, FBS, TG, OGTT and insulin were measured. The case group was then randomly divided into: positive control, E. Billardieri, pioglitazone, and E. Billardieri + pioglitazone groups (N = 6) and treated with (50mg / kg) E. Billardieri and (5mg / kg) pioglitazone by gavage daily for 4 weeks. At the end of treatment, serum samples were prepared again and serum factors were measured by standard laboratory methods. Results: Treatment with high-fat diet significantly increased the weight of animals (P <0.0001). Cholesterol, sugar, triglyceride and insulin levels also increased significantly but HDL-C decreased (P <0.05). HOMA-IR and TYC indices showed a significant increase (P <0.05). Treatment of animals significantly increased HDL-C and decreased other factors (P <0.01). Conclusions: The findings of this study indicate a reduction in insulin resistance by E. Billardieri extract, so it can probably be used as a complementary or alternative treatment for insulin resistance.